I recently created a new sim with additional sliders and then noticed that her eyes and mouth had a different shape compared to cas. In game mode, the lower eyelid is kinda crooked and is much lower, the iris was much bigger than in cas and the mouth is slightly open, plus has a different shape (for example, if I make the lips sharp, in game they will be rounded and vice versa). I tried to fix this with the EA presets, but the problem still remained. After that I pulled all the CC out of the game, but it didn't fix the problem. Meanwhile all sim's created before and after her with custom sliders look the same as in cas.

I believe this usually occurs when a custom slider doesn't have LODs set correctly, and can be fixed by changing the Sim Detail setting to High.