- Sackhoff, Katee: HystericalParoxysm at MTS2 (as Kara Thrace - "Starbuck" from Battlestar Galactica)
- Salo, Ola: sirlemoncurd at MTS2 (of The Ark)
- Sambora, Richie: cougarmadcat at InSIM
- Sanchez, Roselyn: Vicha at MTS
- Sandler, Adam: Mr Rock at MTS
- Santoro, Rodrigo: Vera Marina at MTS2
- Savant, Doug: Jessica_2020 at MTS (as Tom Scavo from Desperate Housewives)
- Scott, Lizabeth: Jessica at Wicked Sims
- Shakur, Tupac: riverofjazz at InSIM
- Sharapova, Maria: steveuk at InSIM
- Shields, Brooke: Vera Marina at MTS
- Sheridan, Nicollette: MaviĀ“Studio at InSIM
- Sevigny, Chloe: Jessica at Wicked Sims
- Shinoda, Mike: Barcelonista at MTS2
- Simmons, Kimora Lee: riverofjazz at InSIM
- Simpson, Jessica:
- Simpson, OJ: DLMulsow at InSIM - (Pimp Daddy version)
- Skin: Go Go Glamour Girl at MTS2 (of Skunk Anansie)
- Somerhalder, Ian:
- Spacek, Sissy: LadyMoonShadow at SS2
- Spears, Britney:
- Staite, Jewel: brendabond at InSIM (as Kaylee from Firefly)
- Statham, Jason: knm3004 at InSIM
- Stegner, Julia: ReginaS at JustSims2
- Stefani, Gwen:
- Stewart, Patrick mistyblue4 MTS
- Sutherland, Keifer: Go Go Glamour Girl MTS
- Swartzenegger, Arnold: Enchantress at Enchanted Forest
- Swit, Loretta: Simpathetic (as Maj. Margaret "Hot Lips" Houlihan from M*A*S*H)
- Sypek, Ryan: knm3004 at InSIM