Removing the hack from the downloads folder usually will fix the problem -
But, sometimes strange things will happen on a lot if a Sim was in the midst of "using" a hack when the game was last saved.
For example, I knew when I installed University that I had to get rid of any hacked careers, which I did.
No problems after the install, except for one lot which would crash as soon as it had loaded.
I finally tracked it down - one of the Sims on the lot had just gotten pregnant before I saved the game, and she was in a hacked career.
The first thing the game wanted to do after the lot loaded was to give her the time off from this career which was no longer there - result was an instant game crash.
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It is also possible for two hacks, each perfectly good and harmless on their own, to interfere with each other if both are used in the game at the same time.
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