Like if it were known that the main characters of the movie were inspired by the Pleasant twins, the Goth family, or the Brokes, even if not a direct copy of them, what would you think of that?

I think Willie Shakespeare wrote a few plays inspired by the Veronaville characters. Some of those plays have been made into films.

Pleasantview is basically Desperate Housewives with a splash of soap opera imo.

Okay, the OP reminded me of an idea I've had kicking around in my head on-and-off for a while:

Your favorite neighborhood in The Sims (any game, any expansion) is getting adapted into a TV series a la The Super Mario Bros. Super Show!: Each episode consists of a number of animated segments, each of which is bookended by live-action skits of the main characters as portrayed by C-list celebrities, career guest stars, and the occasional aging/retired pro wrestler. Which neighborhood would you pick for the show, and who's playing who? (Part of the conceit of Super Show! is that the live-action skits take place some years after the animated segments, so it's fine if the live actors are significantly older than the characters they'll portray.)

As for my pick? Given how risk-averse so many entertainment industry executives are, I doubt many will go for it (in a way that'll do it justice), but I'd really like to see someone depict Strangetown on a TV show budget, with its strangeness intact. Mad scientists, alien pregnancies, and all. No ideas about who's playing who, though.